| 2026-07-11 | Conor McGregor | 10-4 | Striker | W | KO/TKO R1 1:09 | UFC 329: McGregor vs. Holloway 2 |
| 2026-03-07 | Charles Oliveira | 24-11 (1 NC) | Grappler | L | Decision - Unanimous R5 5:00 | UFC 326: Holloway vs. Oliveira 2 |
| 2025-07-19 | Dustin Poirier | 22-8 (1 NC) | Submission grappler | W | Decision - Unanimous R5 5:00 | UFC 318: Holloway vs. Poirier 3 |
| 2024-10-26 | Ilia Topuria | 7-0 | Submission grappler | L | KO/TKO R3 1:34 (title) | UFC 308: Topuria vs. Holloway |
| 2024-04-13 | Justin Gaethje | 8-4 | Striker | W | KO/TKO R5 4:59 | UFC 300: Pereira vs. Hill |
| 2023-08-26 | Chan Sung Jung | 7-4 | Striker | W | KO/TKO R3 0:23 | UFC Fight Night: Holloway vs. The Korean Zombie |
| 2023-04-15 | Arnold Allen | 10-0 | Balanced | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Holloway vs. Allen |
| 2022-07-02 | Alexander Volkanovski | 11-0 | Striker | L | Decision - Unanimous R5 5:00 (title) | UFC 276: Adesanya vs. Cannonier |
| 2021-11-13 | Yair Rodriguez | 8-1 (1 NC) | Striker | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Holloway vs. Rodriguez |
| 2021-01-16 | Calvin Kattar | 6-2 | Striker | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Holloway vs. Kattar |
| 2020-07-11 | Alexander Volkanovski | 8-0 | Wrestler | L | Decision - Split R5 5:00 (title) | UFC 251: Usman vs. Masvidal |
| 2019-12-14 | Alexander Volkanovski | 7-0 | Wrestler | L | Decision - Unanimous R5 5:00 (title) | UFC 245: Usman vs. Covington |
| 2019-07-27 | Frankie Edgar | 17-6-1 | Wrestler | W | Decision - Unanimous R5 5:00 (title) | UFC 240: Holloway vs. Edgar |
| 2019-04-13 | Dustin Poirier | 16-4 (1 NC) | Submission grappler | L | Decision - Unanimous R5 5:00 (title) | UFC 236: Holloway vs. Poirier 2 |
| 2018-12-08 | Brian Ortega | 6-0 (1 NC) | Submission grappler | W | TKO - Doctor's Stoppage R4 5:00 (title) | UFC 231: Holloway vs. Ortega |
| 2017-12-02 | Jose Aldo | 8-2 | Balanced | W | KO/TKO R3 4:51 (title) | UFC 218: Holloway vs. Aldo 2 |
| 2017-06-03 | Jose Aldo | 8-1 | Balanced | W | KO/TKO R3 4:13 (title) | UFC 212: Aldo vs. Holloway |
| 2016-12-10 | Anthony Pettis | 6-4 | Balanced | W | KO/TKO R3 4:50 (title) | UFC 206: Holloway vs. Pettis |
| 2016-06-04 | Ricardo Lamas | 7-2 | Submission grappler | W | Decision - Unanimous R3 5:00 | UFC 199: Rockhold vs. Bisping 2 |
| 2015-12-12 | Jeremy Stephens | 11-10 | Balanced | W | Decision - Unanimous R3 5:00 | UFC 194: Aldo vs McGregor |
| 2015-08-23 | Charles Oliveira | 8-4 (1 NC) | Grappler | W | KO/TKO R1 1:39 | UFC Fight Night: Holloway vs Oliveira |
| 2015-04-18 | Cub Swanson | 6-2 | Balanced | W | Submission R3 3:58 | UFC on FOX: Machida vs Rockhold |
| 2015-02-14 | Cole Miller | 10-6 | Submission grappler | W | Decision - Unanimous R3 5:00 | UFC Fight Night: Henderson vs Thatch |
| 2014-10-04 | Akira Corassani | 3-1 | Balanced | W | KO/TKO R1 3:11 | UFC Fight Night: Nelson vs Story |
| 2014-08-23 | Clay Collard | UFC debut | — | W | KO/TKO R3 3:47 | UFC Fight Night: Henderson vs Dos Anjos |
| 2014-04-26 | Andre Fili | 1-0 | — | W | Submission R3 3:39 | UFC 172: Jones vs Teixeira |
| 2014-01-04 | Will Chope | UFC debut | — | W | KO/TKO R2 2:27 | UFC Fight Night: Saffiedine vs Lim |
| 2013-08-17 | Conor McGregor | 1-0 | — | L | Decision - Unanimous R3 5:00 | UFC Fight Night: Shogun vs Sonnen |
| 2013-05-25 | Dennis Bermudez | 3-1 | Grappler | L | Decision - Split R3 5:00 | UFC 160: Velasquez vs Silva 2 |
| 2012-12-29 | Leonard Garcia | 2-5 | Balanced | W | Decision - Split R3 5:00 | UFC 155: Dos Santos vs Velasquez II |
| 2012-08-11 | Justin Lawrence | 1-0 | — | W | KO/TKO R2 4:49 | UFC 150: Henderson vs Edgar II |
| 2012-06-01 | Pat Schilling | 0-1 | — | W | Decision - Unanimous R3 5:00 | The Ultimate Fighter: Live Finale |
| 2012-02-04 | Dustin Poirier | 3-0 | Wrestler | L | Submission R1 3:23 | UFC 143: Diaz vs Condit |