| 2026-07-11 | Max Holloway | 23-9 | Striker | L | KO/TKO R1 1:09 | UFC 329: McGregor vs. Holloway 2 |
| 2021-07-10 | Dustin Poirier | 19-5 (1 NC) | Submission grappler | L | TKO - Doctor's Stoppage R1 5:00 | UFC 264: Poirier vs. McGregor 3 |
| 2021-01-23 | Dustin Poirier | 18-5 (1 NC) | Submission grappler | L | KO/TKO R2 2:32 | UFC 257: Poirier vs. McGregor |
| 2020-01-18 | Donald Cerrone | 23-10 | Striker | W | KO/TKO R1 0:40 | UFC 246: McGregor vs. Cowboy |
| 2018-10-06 | Khabib Nurmagomedov | 10-0 | Wrestler | L | Submission R4 3:03 (title) | UFC 229: Khabib vs. McGregor |
| 2016-11-12 | Eddie Alvarez | 3-1 | Wrestler | W | KO/TKO R2 3:04 (title) | UFC 205: Alvarez vs McGregor |
| 2016-08-20 | Nate Diaz | 14-8 | Submission grappler | W | Decision - Majority R5 5:00 | UFC 202: Diaz vs. McGregor 2 |
| 2016-03-05 | Nate Diaz | 13-8 | Submission grappler | L | Submission R2 4:12 | UFC 196: McGregor vs Diaz |
| 2015-12-12 | Jose Aldo | 7-0 | Balanced | W | KO/TKO R1 0:13 (title) | UFC 194: Aldo vs McGregor |
| 2015-07-11 | Chad Mendes | 8-2 | Wrestler | W | KO/TKO R2 4:57 (title) | UFC 189: Mendes vs McGregor |
| 2015-01-18 | Dennis Siver | 11-6 (1 NC) | Striker | W | KO/TKO R2 1:54 | UFC Fight Night: McGregor vs Siver |
| 2014-09-27 | Dustin Poirier | 8-2 | Submission grappler | W | KO/TKO R1 1:46 | UFC 178: Johnson vs Cariaso |
| 2014-07-19 | Diego Brandao | 4-2 | Wrestler | W | KO/TKO R1 4:05 | UFC Fight Night: McGregor vs Brandao |
| 2013-08-17 | Max Holloway | 3-2 | Striker | W | Decision - Unanimous R3 5:00 | UFC Fight Night: Shogun vs Sonnen |
| 2013-04-06 | Marcus Brimage | 3-0 | Striker | W | KO/TKO R1 1:07 | UFC on FUEL TV: Mousasi vs Latifi |