| 2026-06-14 | Ilia Topuria | 9-0 | Submission grappler | W | KO/TKO R4 5:00 (title) | UFC Freedom 250 |
| 2026-01-24 | Paddy Pimblett | 7-0 | Submission grappler | W | Decision - Unanimous R5 5:00 (title) | UFC 324: Gaethje vs. Pimblett |
| 2025-03-08 | Rafael Fiziev | 6-3 | Striker | W | Decision - Unanimous R3 5:00 | UFC 313: Pereira vs. Ankalaev |
| 2024-04-13 | Max Holloway | 21-7 | Striker | L | KO/TKO R5 4:59 | UFC 300: Pereira vs. Hill |
| 2023-07-29 | Dustin Poirier | 21-6 (1 NC) | Submission grappler | W | KO/TKO R2 1:00 | UFC 291: Poirier vs. Gaethje 2 |
| 2023-03-18 | Rafael Fiziev | 6-1 | Striker | W | Decision - Majority R3 5:00 | UFC 286: Edwards vs. Usman 3 |
| 2022-05-07 | Charles Oliveira | 20-8 (1 NC) | Grappler | L | Submission R1 3:22 | UFC 274: Oliveira vs. Gaethje |
| 2021-11-06 | Michael Chandler | 1-1 | — | W | Decision - Unanimous R3 5:00 | UFC 268: Usman vs. Covington 2 |
| 2020-10-24 | Khabib Nurmagomedov | 12-0 | Wrestler | L | Submission R2 1:34 (title) | UFC 254: Khabib vs. Gaethje |
| 2020-05-09 | Tony Ferguson | 15-1 | Submission grappler | W | KO/TKO R5 3:39 (title) | UFC 249: Ferguson vs. Gaethje |
| 2019-09-14 | Donald Cerrone | 23-9 | Striker | W | KO/TKO R1 4:18 | UFC Fight Night: Cowboy vs. Gaethje |
| 2019-03-30 | Edson Barboza | 14-6 | Striker | W | KO/TKO R1 2:30 | UFC Fight Night: Barboza vs. Gaethje |
| 2018-08-25 | James Vick | 9-1 | Striker | W | KO/TKO R1 1:27 | UFC Fight Night: Gaethje vs. Vick |
| 2018-04-14 | Dustin Poirier | 14-4 (1 NC) | Grappler | L | KO/TKO R4 0:33 | UFC Fight Night: Poirier vs. Gaethje |
| 2017-12-02 | Eddie Alvarez | 3-2 (1 NC) | Wrestler | L | KO/TKO R3 3:59 | UFC 218: Holloway vs. Aldo 2 |
| 2017-07-07 | Michael Johnson | 9-7 | Striker | W | KO/TKO R2 4:48 | The Ultimate Fighter: Redemption Finale |