| 2025-07-19 | Max Holloway | 22-8 | Striker | L | Decision - Unanimous R5 5:00 | UFC 318: Holloway vs. Poirier 3 |
| 2024-06-01 | Islam Makhachev | 14-1 | Grappler | L | Submission R5 2:42 (title) | UFC 302: Makhachev vs. Poirier |
| 2024-03-09 | Benoit Saint Denis | 5-1 | Grappler | W | KO/TKO R2 2:32 | UFC 299: O'Malley vs. Vera 2 |
| 2023-07-29 | Justin Gaethje | 7-4 | Striker | L | KO/TKO R2 1:00 | UFC 291: Poirier vs. Gaethje 2 |
| 2022-11-12 | Michael Chandler | 2-2 | Striker | W | Submission R3 2:00 | UFC 281: Adesanya vs. Pereira |
| 2021-12-11 | Charles Oliveira | 19-8 (1 NC) | Grappler | L | Submission R3 1:02 (title) | UFC 269: Oliveira vs. Poirier |
| 2021-07-10 | Conor McGregor | 10-3 | Striker | W | TKO - Doctor's Stoppage R1 5:00 | UFC 264: Poirier vs. McGregor 3 |
| 2021-01-23 | Conor McGregor | 10-2 | Striker | W | KO/TKO R2 2:32 | UFC 257: Poirier vs. McGregor |
| 2020-06-27 | Dan Hooker | 10-4 | Striker | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Poirier vs. Hooker |
| 2019-09-07 | Khabib Nurmagomedov | 11-0 | Wrestler | L | Submission R3 2:06 (title) | UFC 242: Khabib vs. Poirier |
| 2019-04-13 | Max Holloway | 16-3 | Striker | W | Decision - Unanimous R5 5:00 (title) | UFC 236: Holloway vs. Poirier 2 |
| 2018-07-28 | Eddie Alvarez | 4-2 (1 NC) | Wrestler | W | KO/TKO R2 4:05 | UFC Fight Night: Alvarez vs. Poirier 2 |
| 2018-04-14 | Justin Gaethje | 1-1 | Striker | W | KO/TKO R4 0:33 | UFC Fight Night: Poirier vs. Gaethje |
| 2017-11-11 | Anthony Pettis | 7-5 | Balanced | W | KO/TKO R3 2:08 | UFC Fight Night: Poirier vs. Pettis |
| 2017-05-13 | Eddie Alvarez | 3-2 | Wrestler | NC | Could Not Continue R2 4:02 | UFC 211: Miocic vs. Dos Santos |
| 2017-02-11 | Jim Miller | 17-7 (1 NC) | Submission grappler | W | Decision - Majority R3 5:00 | UFC 208: Holm vs. De Randamie |
| 2016-09-17 | Michael Johnson | 8-6 | Striker | L | KO/TKO R1 1:35 | UFC Fight Night: Poirier vs. Johnson |
| 2016-06-04 | King Green | 4-1 | Striker | W | KO/TKO R1 2:53 | UFC 199: Rockhold vs. Bisping 2 |
| 2016-01-02 | Joe Duffy | 2-0 | — | W | Decision - Unanimous R3 5:00 | UFC 195: Lawler vs Condit |
| 2015-06-06 | Yancy Medeiros | 2-2 (1 NC) | Submission grappler | W | KO/TKO R1 2:38 | UFC Fight Night: Boetsch vs Henderson |
| 2015-04-04 | Diego Ferreira | 2-1 | Submission grappler | W | KO/TKO R1 3:45 | UFC Fight Night: Mendes vs Lamas |
| 2014-09-27 | Conor McGregor | 3-0 | Wrestler | L | KO/TKO R1 1:46 | UFC 178: Johnson vs Cariaso |
| 2014-04-16 | Akira Corassani | 3-0 | Balanced | W | KO/TKO R2 0:42 | UFC Fight Night: Bisping vs Kennedy |
| 2013-12-28 | Diego Brandao | 4-1 | Wrestler | W | KO/TKO R1 4:54 | UFC 168: Weidman vs Silva 2 |
| 2013-08-31 | Erik Koch | 2-1 | Balanced | W | Decision - Unanimous R3 5:00 | UFC 164: Henderson vs Pettis 2 |
| 2013-02-16 | Cub Swanson | 3-1 | Striker | L | Decision - Unanimous R3 5:00 | UFC on FUEL TV: Barao vs McDonald |
| 2012-12-15 | Jonathan Brookins | 2-2 | Wrestler | W | Submission R1 4:15 | The Ultimate Fighter: Team Carwin vs. Team Nelson Finale |
| 2012-05-15 | Chan Sung Jung | 2-0 | — | L | Submission R4 1:07 | UFC on FUEL TV: Korean Zombie vs Poirier |
| 2012-02-04 | Max Holloway | UFC debut | — | W | Submission R1 3:23 | UFC 143: Diaz vs Condit |
| 2011-11-12 | Pablo Garza | 2-0 | — | W | Submission R2 1:32 | UFC on FOX: Velasquez vs Dos Santos |
| 2011-06-11 | Jason Young | UFC debut | — | W | Decision - Unanimous R3 5:00 | UFC 131: Dos Santos vs Carwin |
| 2011-01-01 | Josh Grispi | UFC debut | — | W | Decision - Unanimous R3 5:00 | UFC 125: Resolution |