| 2026-07-18 | Dricus Du Plessis | 9-1 | Wrestler | L | Decision - Unanimous R5 5:00 | UFC Fight Night: Du Plessis vs. Usman |
| 2025-06-14 | Joaquin Buckley | 11-4 | Striker | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Usman vs. Buckley |
| 2023-10-21 | Khamzat Chimaev | 6-0 | Grappler | L | Decision - Majority R3 5:00 | UFC 294: Makhachev vs. Volkanovski 2 |
| 2023-03-18 | Leon Edwards | 12-2 (1 NC) | Balanced | L | Decision - Majority R5 5:00 (title) | UFC 286: Edwards vs. Usman 3 |
| 2022-08-20 | Leon Edwards | 11-2 (1 NC) | Balanced | L | KO/TKO R5 4:04 (title) | UFC 278: Usman vs. Edwards |
| 2021-11-06 | Colby Covington | 11-2 | Wrestler | W | Decision - Unanimous R5 5:00 (title) | UFC 268: Usman vs. Covington 2 |
| 2021-04-24 | Jorge Masvidal | 12-7 | Striker | W | KO/TKO R2 1:02 (title) | UFC 261: Usman vs. Masvidal 2 |
| 2021-02-13 | Gilbert Burns | 12-3 | Wrestler | W | KO/TKO R3 0:34 (title) | UFC 258: Usman vs. Burns |
| 2020-07-11 | Jorge Masvidal | 12-6 | Striker | W | Decision - Unanimous R5 5:00 (title) | UFC 251: Usman vs. Masvidal |
| 2019-12-14 | Colby Covington | 10-1 | Wrestler | W | KO/TKO R5 4:10 (title) | UFC 245: Usman vs. Covington |
| 2019-03-02 | Tyron Woodley | 9-2-1 | Balanced | W | Decision - Unanimous R5 5:00 (title) | UFC 235: Jones vs. Smith |
| 2018-11-30 | Rafael Dos Anjos | 17-8 | Wrestler | W | Decision - Unanimous R5 5:00 | The Ultimate Fighter: Heavy Hitters Finale |
| 2018-05-19 | Demian Maia | 19-8 | Grappler | W | Decision - Unanimous R5 5:00 | UFC Fight Night: Maia vs. Usman |
| 2018-01-14 | Emil Meek | 1-0 | Submission grappler | W | Decision - Unanimous R3 5:00 | UFC Fight Night: Stephens vs. Choi |
| 2017-09-16 | Sergio Moraes | 6-1-1 | Balanced | W | KO/TKO R1 2:48 | UFC Fight Night: Rockhold vs. Branch |
| 2017-04-08 | Sean Strickland | 5-1 | Striker | W | Decision - Unanimous R3 5:00 | UFC 210: Cormier vs. Johnson 2 |
| 2016-11-19 | Warlley Alves | 4-1 | Submission grappler | W | Decision - Unanimous R3 5:00 | UFC Fight Night: Bader vs. Nogueira |
| 2016-07-23 | Alexander Yakovlev | 2-2 | Balanced | W | Decision - Unanimous R3 5:00 | UFC on FOX: Holm vs. Shevchenko |
| 2015-12-19 | Leon Edwards | 2-1 | Balanced | W | Decision - Unanimous R3 5:00 | UFC on FOX: Dos Anjos vs. Cowboy 2 |
| 2015-07-12 | Hayder Hassan | UFC debut | — | W | Submission R2 1:19 (title) | The Ultimate Fighter: American Top Team vs. Blackzilians Finale |