| 2026-06-14 | Josh Hokit | 3-0 | Striker | L | KO/TKO R2 4:09 | UFC Freedom 250 |
| 2026-01-24 | Waldo Cortes Acosta | 9-2 | Striker | L | KO/TKO R2 3:14 | UFC 324: Gaethje vs. Pimblett |
| 2025-07-12 | Tallison Teixeira | 1-0 | — | W | KO/TKO R1 0:35 | UFC Fight Night: Lewis vs. Teixeira |
| 2024-05-11 | Rodrigo Nascimento | 4-1 (1 NC) | Striker | W | KO/TKO R3 0:49 | UFC Fight Night: Lewis vs. Nascimento |
| 2023-11-04 | Jailton Almeida | 5-0 | Grappler | L | Decision - Unanimous R5 5:00 | UFC Fight Night: Almeida vs. Lewis |
| 2023-07-29 | Marcos Rogerio de Lima | 10-6 | Balanced | W | KO/TKO R1 0:33 | UFC 291: Poirier vs. Gaethje 2 |
| 2023-02-04 | Serghei Spivac | 6-3 | Wrestler | L | Submission R1 3:05 | UFC Fight Night: Lewis vs. Spivac |
| 2022-07-30 | Sergei Pavlovich | 3-1 | — | L | KO/TKO R1 0:55 | UFC 277: Pena vs. Nunes 2 |
| 2022-02-12 | Tai Tuivasa | 7-3 | Striker | L | KO/TKO R2 1:40 | UFC 271: Adesanya vs. Whittaker 2 |
| 2021-12-18 | Chris Daukaus | 4-0 | — | W | KO/TKO R1 3:36 | UFC Fight Night: Lewis vs. Daukaus |
| 2021-08-07 | Ciryl Gane | 6-0 | Striker | L | KO/TKO R3 4:11 (title) | UFC 265: Lewis vs. Gane |
| 2021-02-20 | Curtis Blaydes | 9-2 (1 NC) | Wrestler | W | KO/TKO R2 1:26 | UFC Fight Night: Blaydes vs. Lewis |
| 2020-08-08 | Aleksei Oleinik | 8-4 | Grappler | W | KO/TKO R2 0:21 | UFC Fight Night: Lewis vs. Oleinik |
| 2020-02-08 | Ilir Latifi | 7-5 | Balanced | W | Decision - Unanimous R3 5:00 | UFC 247: Jones vs. Reyes |
| 2019-11-02 | Blagoy Ivanov | 2-1 | Balanced | W | Decision - Split R3 5:00 | UFC 244: Masvidal vs. Diaz |
| 2019-03-09 | Junior Dos Santos | 14-4 | Striker | L | KO/TKO R2 1:58 | UFC Fight Night: Lewis vs. Dos Santos |
| 2018-11-03 | Daniel Cormier | 10-1 (1 NC) | Striker | L | Submission R2 2:14 (title) | UFC 230: Cormier vs. Lewis |
| 2018-10-06 | Alexander Volkov | 4-0 | Striker | W | KO/TKO R3 4:49 | UFC 229: Khabib vs. McGregor |
| 2018-07-07 | Francis Ngannou | 6-1 | Balanced | W | Decision - Unanimous R3 5:00 | UFC 226: Miocic vs. Cormier |
| 2018-02-18 | Marcin Tybura | 3-2 | Striker | W | KO/TKO R3 2:48 | UFC Fight Night: Cerrone vs. Medeiros |
| 2017-06-10 | Mark Hunt | 7-5-1 (1 NC) | Balanced | L | KO/TKO R4 3:51 | UFC Fight Night: Lewis vs. Hunt |
| 2017-02-19 | Travis Browne | 9-5-1 | Balanced | W | KO/TKO R2 3:12 | UFC Fight Night: Lewis vs. Browne |
| 2016-12-09 | Shamil Abdurakhimov | 2-1 | Balanced | W | KO/TKO R4 3:42 | UFC Fight Night: Lewis vs. Abdurakhimov |
| 2016-07-07 | Roy Nelson | 8-8 | Balanced | W | Decision - Split R3 5:00 | UFC Fight Night: Dos Anjos vs. Alvarez |
| 2016-04-10 | Gabriel Gonzaga | 12-9 | Grappler | W | KO/TKO R1 4:48 | UFC Fight Night: Rothwell vs Dos Santos |
| 2016-02-06 | Damian Grabowski | UFC debut | — | W | KO/TKO R1 2:17 | UFC Fight Night: Hendricks vs Thompson |
| 2015-10-03 | Viktor Pesta | 1-1 | Wrestler | W | KO/TKO R3 1:15 | UFC 192: Cormier vs Gustafsson |
| 2015-06-06 | Shawn Jordan | 5-3 | Balanced | L | KO/TKO R2 0:48 | UFC Fight Night: Boetsch vs Henderson |
| 2015-02-28 | Ruan Potts | 0-2 | — | W | KO/TKO R2 3:18 | UFC 184: Rousey vs Zingano |
| 2014-09-05 | Matt Mitrione | 7-3 | Striker | L | KO/TKO R1 0:41 | UFC Fight Night: Jacare vs Mousasi |
| 2014-07-06 | Guto Inocente | UFC debut | — | W | KO/TKO R1 3:30 | The Ultimate Fighter: Team Edgar vs. Team Penn Finale |
| 2014-04-19 | Jack May | UFC debut | — | W | KO/TKO R1 4:23 | UFC on FOX: Werdum vs Browne |