San Francisco 49ers predictions and picks

Mako Bets writes a full preview of every San Francisco 49ers game: the matchup, the players who decide it, injuries and the line.

Earlier previews

• San Francisco 49ers at Atlanta Falcons prediction · Sun, Oct 25, 2026 · San Francisco 49ers -2.5, total 50
  Without Evans and Samuel, Purdy tests Atlanta's 29th-ranked pass defense

All NFL predictions